Review: Correlation between Type 1 Diabetes Mellitus and Gut Microbiome

Document Type : Original Article


1 Department of Clinical Nutrition, National Nutrition Institute NNI, Cairo, Egypt.

2 Ministry of Health and Population, Cairo, Egypt

3 Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt


Diabetes mellitus (DM) is one of the most common metabolic disorders all over the world. Type 1 diabetes (T1D) is a subtype of DM that is characterized by autoimmunity and B-cell destruction. T1D is considered a disease of multifactorial origin with genetic susceptibility and environmental factors. The environmental (triggering) factors are numerous and including gut microbiome (GM). GM is a humorous dynamic population of microbes that harbor the intestine and have a marked effect on our metabolic diseases and homeostasis. Many studies found that dysbiosis and compositional changes in GM play important roles in T1D development. The objective of this study was to determine the correlation between T1D and GM to establish the best strategies for microbiome alteration to assist in the prevention of T1D occurrence and for better glycaemic control in the near future. The search studies address the question of the relationship between T1D and GM. All available data provided by PubMed/MEDLINE, Google Scholar, Springer Link, EM base Medline, and Cochrane Library were reviewed to fulfill the required objectives. Conclusion: Diet can alter the onset and course of autoimmune disorders including T1D by modifying the gut microbiome.


Main Subjects