Protective Effect of Nettle and Olive Leaves on Hyperlipidemia in Experimental Rats

Document Type : Original Article

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Nutrition and Food Science Dept., Faculty of Home Economics, Al-Azhar University, Egypt

Abstract

D





yslipidemia is a major contributor to atherosclerotic cardiovascular disease. Recently, World Health Organization (WHO) reported that cardiovascular diseases (CVD) account for 46% of ever all mortality in Egypt. So that; the present study investigated, the protective effect of nettle and olive leaves on hyperlipidemia in experimental rats. Thirty six male albino rats weighing 130 ± 20 g used in this study and  divided into equal six groups ( 6 rats each),the first  kept as anegative control group (-ve) received basal diet  throughout the experiment period, while  the second  was the (+ve) control group which fed on hyperlipidemic diet for four weeks, while the four others groups given hyperlipidemic diet  supplemented with   nettle leaves  (5%) ,( 10 %)  and olive leaves(5 %), (10%)   respectively for four weeks (astreatment groups ) .The chemical composition and phenolic compounds of  both leaves were done .  At the end of the experiment, biological data were calculated; blood samples were taken to biochemical analysis. In addition, histopathological examination was done. The results revealed that hyperlipidemic diet  in the (+ve) control group increased body weight gain ,relative organ weight, serum lipid profile, Malondialdhyde (MDA), liver enzymes and serum glucose, decreased in serum HDL-C, serum Superoxide Dismutase (SOD),  and Glutathione Peroxidase (GPx)  .  All treated groups with two leaves showed improvement previously parameters compared with positive control group. In conclusion, the consumption of nettle and olive leaves could be used for improving lipid profile, liver function and protect from hyperlipidemia in experimental rats. 

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