Protective Effect of the Red Quinoa Seeds versus Oxidative Stress Induced by Alloxan and Carbon Tetrachloride in Experimental Rats

Document Type : Original Article


1 Home Economic Dept., Faculty of Specific Education, Ain Shams University, Cairo, Egypt

2 GC-MS lab, National Nutrition Institute, Cairo, Egypt

3 Home Economic Dept., Faculty of Specific Education, Ain Shams University,Cairo, Egypt


The Red Quinoa seeds (RQ seeds) shows a higher number of total phenolic and flavonoids content. Therefore, the protective effect of the RQ seeds versus oxidative stress induced by Alloxan and carbon tetrachloride (CCl4) may treatment in rats. Fifty-six healthy male albino rats were randomly divided into three main groups. The first group of healthyrats (8 rats) was negative control and fed on commercial diet. The second group (24 rats) received CCl4 injections subcutaneously (for two weeks); while, the third group (24 rats) were fasted for 24 hours, injected with one dose prepared Alloxan by intraperitoneal injection to induce oxidative Stress. Then both main 2 groups were divided into 3 subgroups (8rats /each) and treated by different concentrations of RQ seedsas for 6 weeks. The rats were weighed weekly and at the end of the experimental, the animals were fasted overnight, anesthetized; sacrificed and weighted the organs excise” liver, kidney and Pancreas”. Results showed that stress groups (Alloxan and CCl4) were significantly increased risk for oxidative stress. However, the results indicated that a diet fortified at 5g and 10g RQ seeds improves weight gain, increased antioxidant enzymes (SOD, CAT and GPx), reduces liver enzymes, kidney function, lipid profiles, serum glucose and reduces the risk of organ functions (liver, kidney and pancreas), related to oxidative stress, when compared to stress groups. More specifically, a diet with 10g RQ seeds reduced the adverse effect of oxidative stress.


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