Amelioration of Cisplatin Induced Sexual Toxicity on Male Rats by Using Fortified of Flat Bread with Moringa Oleifera

Document Type : Original Article


1 Faculty of Home Economics, the Public Authority for Applied Education and Training, Kuwait

2 Department of Home Economics, Faculty of Specific Education, Mansoura University, Egypt


The study aim to investigat the effect of fortification of flat bread with moringa oleifera aganist cisplatin induced sexual toxicity in male rats and evaluates the sensory characteristics and the nutritive value of the fortified bread prepared against cisplatin. Chemical composition of flat bread, flat bread fortified by moringa powder and oil were determined. To induce sexual toxicity, male rats were given cisplatin by (12 mg/kg body weight). Thirty five male rats were classified into seven groups (n=5). The first group was kept as negative control group, while the other six groups were injected with cisplatin to induce toxicity in various experimental animals; one of those groups was fed on basal diet only and served as positive control group (G2). The third group (G3) was fed on basal diet and treated with control flat bread (100% wheat flour). The fourth and fifth (G4&G5) groups were fed on basal diet containing fortified flat bread with 10% & 15% moringa powder respectively. The sixth and seventh (G6&G7) were fed on basal diet containing fortified flat bread with 5 ml and 10 ml moringa oil respectively. Results: The results revealed that rats consumed fortified flat bread with moringa powder and oil showed significant increases in follicle stimulating hormone level (FSH), and luteinizing hormone (LH), compared with the positive control. Administration of moringa powder and oil improved kidney function, liver enzymes and antioxidant parameters in male rats. In the current study, the protective effect of moringa powder and oil against cisplatin induced sexual toxicity in rats was improved. Conclusions: Moringa powder and oil may be used to prevent toxicity during chemotherapeutic treatment with cisplatin.