Dietary Intervention of Coconut Liquid to Mitigate the Hyperlipidemia in Rats

Document Type : Original Article

Authors

1 Chemistry of Nutrition and metabolism department, National Nutrition Institute (NNI) –Cairo, Egypt

2 Food science department, National Nutrition Institute (NNI) –Cairo, Egypt

3 Nutrition department- Hepatology and Tropical Medicine National Institute–Cairo, Egypt

4 Field Studies and Survey department, National Nutrition Institute (NNI) –Cairo, Egypt

5 Natural resources department- Faculty of African Post Graduated Studies–Cairo, Egypt

Abstract

 Coconut liquid (CL) is a natural drink that contains many bioactive nutrients.  Hyperlipidemia is a heterogeneous group of disorders characterized by abnormal levels of prevalent lipids and lipoproteins. This study aims to evaluate the effect of nutrients in coconut liquid on hyperlipidemia in male albino rats.  Animals were divided into four classes: healthy rats, healthy rats that induced hyperlipidemia by a high-fat diet.  Rats with hyperlipidemia were supplemented their diet with CL at 2 doses of 100; 500 mg/kg food for four weeks. The biological parameters were measured (feed intake, body weight gain).  The liver functions were (transaminase alanine, transaminase aspartate, and alkaline phosphate). Hyperlipidemia markers were (triglycerides “TG”, high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), very low-density lipoprotein (VLDL-c), total cholesterol, and atherogenic coefficient “AC”); and histological examination.  The results were showed the rats that fed on coconut beverage with two-dose change for better than hyperlipidemic rats of all parameters (biological, biochemical, and histopathological). The overall results show that coconut water (CW) has significant beneficial effects in hyperlipidemic rats.

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