Therapeutic effects of Curcumin, Saffron, and Moringa against Aluminum Toxicity in Rats

Document Type : Original Article

Authors

1 Department of Home Economics Nutrition and Food Sciences, Faculty of Specific Education - Ain Shams University,

2 Nutritional Chemistry and Metabolism Department, National Nutrition Institute (NNI) –Cairo, Egypt

3 Department of Home Economics Nutrition and Food Sciences, Faculty of Specific Education - Ain Shams University

Abstract

Natural plants can help treat some diseases and are a great source of vitamins and minerals for the body. Objective: research the use of moringa, saffron, and curcumin to treat animals from aluminum poisoning. Thirty-five male albino rats weighing around 170 ± 10g were divided into 5 groups (7 rats/ each) as follows: The main first group was kept as a negative control and was fed on the basal diet only. The second main group (28 rats) after six weeks of feeding a normal diet supplemented with aluminum chloride (AlCl3), was divided into four subgroups fed AlCl3 and treated plants for a further four weeks. The first was a positive group that consumed a normal diet with AlCl3. A basal diet mixed with AlCl3 + Moringa (100 mg/kg diet) was provided to subgroup 2.  The consumption of a basal diet combined with 15 mg/kg of saffron and AlCl3 supplied subgroup 3. A basal diet mixed with AlCl3 and curcumin (0.5 g/kg diet) was given to subgroup 4. The findings showed that the plant with the greatest potential to reduce aluminum toxicity was saffron, while moringa improved liver and kidney functions and curcumin helped ameliorate the lipid profile. In conclusion, employing these natural plants can reduce the severity of aluminum poisoning.

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